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KMID : 0369820080380050331
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Jorunal of Korean Pharmaceutical Sciences
2008 Volume.38 No. 5 p.331 ~ p.334
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Pharmacokinetics and Oral Bioavailability of Paclitaxel Microemulsion in Rats
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Hur Hye-Jung
Park Joon-Hee
Kim Seo-Young
Yang Hyun-Kyoung
Kim Ji-Hyeon
Ryu Jae-Kuk
Woo Jong-Soo
Lee Byung-Koo
Lee Hwa-Jeong
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Abstract
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The objectives of this study were to formulate oral paclitaxel microemulsion and to compare the bioavailability of paclitaxel in the microemulsion formulation from the commercially available Taxol(R) formulation. Paclitaxel microemulsion was formulated with much less amount of Cremophor EL™ as compared with Taxol(R) to reduce severe adverse reactions produced by Cremophor EL™. The area under the plasma concentration-time curve from 0 hr to 24 hr (AUCo-24), maximum plasma concentration (Cmax), maximum plasma concentration Taxol(R) after oral administration. The time required to reach Cmax(Tmax) of palcitaxel microemulsion was significantly shorter than Taxol(R) following oral administration. These results suggest the faster intestinal absorption and the enhanced oral bioavailability of paclitaxel in the microemulsion formulation.
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KEYWORD
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Paclitaxel microemulsion, Pharmacokinetics, Oral bioavailability
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